China (Mainland)
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Newblue CHEM----A-83-01 CAS NO.909910-43-6
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T,
- Product Details
Keywords
- A-83-01
- 909910-43-6
- good quality
Quick Details
- ProName: Newblue CHEM----A-83-01
- CasNo: 909910-43-6
- Molecular Formula: C25H19N5S
- Appearance: Colorless to light yellow liquid
- Application: Water treatment
- DeliveryTime: depends on yr quantity
- PackAge: 20kg/drum, 200kg/drum or 1000kg/IBC Dr...
- Port: china mian port
- ProductionCapacity: 10 Metric Ton/Month
- Purity: 98
- Storage: Room temperature
- Transportation: By sea , by air or express
- LimitNum: 1 Kilogram
- Grade: Industrial Grade,Electron Grade
- Purity: 98% Min
Superiority
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:
1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
Our advantage:
1. Higest quality and good package
2.Fast delivery
3.Better payment term
4.Fast response to customer within 6 hours
5.Good business credit in Europe ,US ,Japan ,Korea
Anyway ,if you need any chemicals from China ,Henan Newblue can help you
Details
| A-83-01 Basic information |
| Product Name: | A-83-01 |
| Synonyms: | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide;A 83-01, >=98%;TGF inhibitor A-83-01;3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide |
| CAS: | 909910-43-6 |
| MF: | C25H19N5S |
| MW: | 421.526 |
| EINECS: | |
| Product Categories: | Protein Kinase;TGF-beta/Smad;Inhibitors |
| Mol File: | 909910-43-6.mol |
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| A-83-01 Chemical Properties |
| mp | 111℃ |
| storage temp. | Store at -20°C |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| A-83-01 Usage And Synthesis |
| Usage | A 83-01 is a selective inhibitor of TGF-β type I receptor. A 83-01 treatment increases tumor permeability. |
| Biological Activity | Selective inhibitor of TGF- β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC 50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF- β -induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol -2-yl]benzamide). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. |