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Product Name: Ramipril
Synonyms: (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid;RaMipril(Altace);(2S,3aS,6aS)-;RaMipril API;Ranipril;PRAMACE;RAMIPRIL;RAMACE
CAS: 87333-19-5
MF: C23H32N2O5
MW: 416.51
EINECS:
Product Categories: API;Cardiovascular & Blood System Agents;Active Pharmaceutical Ingredients;Ramipril;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Angiotensin
Mol File: 87333-19-5.mol
Ramipril Structure
Ramipril Chemical Properties
Melting point  106-108°C
alpha  D24 +33.2° (c = 1 in 0.1N ethanolic HCl)
storage temp.  2-8°C
solubility  DMSO: ~18mg/mL
color  white
CAS DataBase Reference 87333-19-5(CAS DataBase Reference)
Safety Information
Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-37/39
RTECS  GY5879600

Ramipril Usage And Synthesis
Description Ramipril (brand name: Altace) is a kind of prodrug which is capable of inhibiting the angiotensin-converting enzyme (ACE) which converting angiotensin I to angiotensin II. It is metabolized to ramiprilat in the liver which exerts the effect of ACE inhibition. It is used for the treatment of hypertension, congestive heart failure and nephropathy. It can also be used for the prevention of heart attack, stroke and cardiovascular death. It can also be used for the treatment of kidney damage due to diabetes with protein-containing urine. Ramiprilat, is the competitive inhibitor of ATI for binding to ACE, further inhibiting the enzymatic proteolysis of ATI to ATII, alleviating the effect of ATII on blood pressure.
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Chemical Properties White Solid
Uses cardiotonic
Uses An inhibitor of the angiotensin- coverting enzyme (ACE)
Uses An antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite
Definition ChEBI: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
Uses Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]