high quality Pimaricin CAS NO.7681-93-8
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- Min.Order: 1 Gram
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- Product Details
Keywords
- Pimaricin
- high purity Pimaricin
- factory supply Pimaricin
Quick Details
- ProName: high quality Pimaricin
- CasNo: 7681-93-8
- Molecular Formula: C33H47NO13
- Appearance: Colorless to light yellow liquid
- Application: Used in a base-free iridium-catalyzed ...
- DeliveryTime: With about 7-10 days after receipt the...
- PackAge: as you requested
- Port: China main port
- ProductionCapacity: 10 Kilogram/Day
- Purity: 99%
- Storage: room temperature
- Transportation: by courier
- LimitNum: 1 Gram
- Transportation: by courier
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Details
CAS: | 7681-93-8 |
MF: | C33H47NO13 |
MW: | 665.73 |
EINECS: | 231-683-5 |
Product Categories: | ERGOSTAT;antibiotic;Food additive;raw materials;Food & Feed ADDITIVES;Antifungal (Topical);Intermediates & Fine Chemicals;Pharmaceuticals;food additives |
Mol File: | 7681-93-8.mol |
Pimaricin Chemical Properties |
Melting point | 2000C (dec) |
Boiling point | 952℃ |
alpha | D20 +278° (c = 1 in CH3COOH) |
density | 1.0 g/mL at 20 °C(lit.) |
Fp | >110°(230°F) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO |
form | aqueous suspension |
Sensitive | Light Sensitive |
Merck | 13,6453 |
Stability: | Light sensitive |
Safety Information |
Hazard Codes | Xn |
Risk Statements | 22 |
Safety Statements | 24/25-36 |
WGK Germany | 2 |
RTECS | TK3325000 |
F | 8-10 |
MSDS Information |
Provider | Language |
---|---|
Pimaricin | English |
SigmaAldrich | English |
Pimaricin Usage And Synthesis |
Description | Pimaricin (also known as natamycin, INN) belongs to a naturally occurring antifungal agent produced through the fermentation of the bacterium Streptomyces natalensis. It is a kind of macrolide polyene antifungal used for the treatment of fungal keratitis, which is a kind of eye infection. In medical field, it can be used for the treatment of various kind of fungal infections caused by Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium. In food industry, it can be used as a natural preservative to prevent fungal outgrowth. Its mechanism of action is through binding to the ergosterol in the plasma membrane of fungi, inhibiting the process of ergosterol-dependent fusion of vacuoles and membrane fusion, further inhibiting the fungal growth. It also inhibit the transport of amino acid and glucose through inhibiting membrane transport proteins. |
References |
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Chemical Properties | White to Off-White Solid |
Uses | Polyene antifungal antibiotic |
Uses | analgesic, antimigraine |
Uses | Pimaricin is a macrocyclic tetraene originally isolated from Streptomyces natalensis in 1957. Pimaricin exhibits broad spectrum antifungal activity against yeast and filamentous fungi by binding specifically to ergosterol to block fungal growth. Unlike the related polyenes, nystatin and filipin, pimaricin does not change the permeability of the plasma membrane. Pimaricin is used in the food industry for surface treatment of cheeses as a mould inhibitor. |