Product Name: Ethyl bromodifluoroacetate
Synonyms: Ethylbromdifluoracetat;2-broMo-2,2-difluoroacetate;2-Bromo-2,2-difluoro-1-ethoxyethan-1-one, 2-Bromo-2,2-difluoro-1-ethoxy-1-oxoethane, Bromo(difluoro)acetic acid ethyl ester;Ethyl broMoacetatetwo fluorine;Twoethyl broMidefluoride;Acetic acid, bromodifluoro-, ethyl ester;2,2-difluoro-2-bromoacetate ethyl;Ethyl bromodifluoroacetate 98%
CAS: 667-27-6
MF: C4H5BrF2O2
MW: 202.98
EINECS: 211-567-0
Product Categories: Chemical Synthesis;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Pharmaceutical Intermediates;Fluoro-containing compounds;API intermediates;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;Fluoro series;C2 to C5;Carbonyl Compounds;Esters;Alkyl Fluorinated Building Blocks;Building Blocks;C2 to C5;Carbonyl Compounds
Mol File: 667-27-6.mol

Ethyl bromodifluoroacetate Chemical Properties
Boiling point  112 °C700 mm Hg(lit.)
density  1.583 g/mL at 25 °C(lit.)
refractive index  n20/D 1.387(lit.)
Fp  70 °F
storage temp.  Flammables area
solubility  Soluble in most organic solvents.
form  Liquid
Specific Gravity 1.583
color  Clear colorless to slightly yellow
BRN  1906095
InChIKey IRSJDVYTJUCXRV-UHFFFAOYSA-N
CAS DataBase Reference 667-27-6(CAS DataBase Reference)
NIST Chemistry Reference Ethyl bromodifluoroacetate(667-27-6)
Safety Information
Hazard Codes  C,F,Xi
Risk Statements  10-34-36
Safety Statements  26-36/37/39-45-16-27
RIDADR  UN 2924 3/PG 2
WGK Germany  3
Hazard Note  Irritant/Flammable
TSCA  No
HazardClass  3
PackingGroup  II
HS Code  29159000

Ethyl bromodifluoroacetate Usage And Synthesis
Chemical Properties clear colorless to slightly yellow liquid
Uses Ethyl bromodifluoroacetate is usually used in the preparation of substituted ethyl 2′-pyridyldifluoroacetates,4-alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines,α,α-difluoro-β-lactams,mono- and difluoromethylated phenanthridine derivatives.
Uses Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis.

Product Name: Ethyl bromodifluoroacetate
Synonyms: Ethylbromdifluoracetat;2-broMo-2,2-difluoroacetate;2-Bromo-2,2-difluoro-1-ethoxyethan-1-one, 2-Bromo-2,2-difluoro-1-ethoxy-1-oxoethane, Bromo(difluoro)acetic acid ethyl ester;Ethyl broMoacetatetwo fluorine;Twoethyl broMidefluoride;Acetic acid, bromodifluoro-, ethyl ester;2,2-difluoro-2-bromoacetate ethyl;Ethyl bromodifluoroacetate 98%
CAS: 667-27-6
MF: C4H5BrF2O2
MW: 202.98
EINECS: 211-567-0
Product Categories: Chemical Synthesis;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Pharmaceutical Intermediates;Fluoro-containing compounds;API intermediates;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;Fluoro series;C2 to C5;Carbonyl Compounds;Esters;Alkyl Fluorinated Building Blocks;Building Blocks;C2 to C5;Carbonyl Compounds
Mol File: 667-27-6.mol

Ethyl bromodifluoroacetate Chemical Properties
Boiling point  112 °C700 mm Hg(lit.)
density  1.583 g/mL at 25 °C(lit.)
refractive index  n20/D 1.387(lit.)
Fp  70 °F
storage temp.  Flammables area
solubility  Soluble in most organic solvents.
form  Liquid
Specific Gravity 1.583
color  Clear colorless to slightly yellow
BRN  1906095
InChIKey IRSJDVYTJUCXRV-UHFFFAOYSA-N
CAS DataBase Reference 667-27-6(CAS DataBase Reference)
NIST Chemistry Reference Ethyl bromodifluoroacetate(667-27-6)
Safety Information
Hazard Codes  C,F,Xi
Risk Statements  10-34-36
Safety Statements  26-36/37/39-45-16-27
RIDADR  UN 2924 3/PG 2
WGK Germany  3
Hazard Note  Irritant/Flammable
TSCA  No
HazardClass  3
PackingGroup  II
HS Code  29159000

Ethyl bromodifluoroacetate Usage And Synthesis
Chemical Properties clear colorless to slightly yellow liquid
Uses Ethyl bromodifluoroacetate is usually used in the preparation of substituted ethyl 2′-pyridyldifluoroacetates,4-alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines,α,α-difluoro-β-lactams,mono- and difluoromethylated phenanthridine derivatives.
Uses Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis.