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Potassium clavulanate Basic information
Product Name: Potassium clavulanate
Synonyms: CLAVULANATE POTASSIUM;CLAVULANIC ACID POTASSIUM;CLAVULANIC ACID POTASSIUM SALT;CLAVULANTE POTASSIUM;POTASSIUM CLAVULANATE;potassium (z)-(2r,5r)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate;brl14151k;monopotassiumsalt,(2r-(2-alpha,3z,5-alpha))-xo
CAS: 61177-45-5
MF: C8H8KNO5
MW: 237.25
EINECS: 262-640-9
Product Categories: All Inhibitors;Antibiotic Explorer;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pharma;Amines;Heterocycles;antibiotic
Mol File: 61177-45-5.mol
Potassium clavulanate Structure
Potassium clavulanate Chemical Properties
Melting point  >1600C (dec)
storage temp.  2-8°C
CAS DataBase Reference 61177-45-5(CAS DataBase Reference)
Safety Information
Hazard Codes  F,Xn,Xi
Risk Statements  11-42/43-44-36-14
Safety Statements  8-16-22-36/37-45-43-26
RIDADR  UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
WGK Germany  2
RTECS  RN6802700

Potassium clavulanate Usage And Synthesis
Chemical Properties Pale Yellowish Solid
Uses Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
Uses Clavulanic acid is a β-lactam antibiotic produced by several species of Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic, but is a potent inhibitor of β-lactamases. In combination with penicillin and cephalosporins, it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the β-lactamase.
Uses A -Lactamase inhibitor, typically added to amoxicillin to increase its effectiveness
Definition ChEBI: A potassium salt having clavulanate as the counterion. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes and has only weak anitbiotic activity when administered alone. However it can be used in combination with amoxicillin trihydrate (under the trade name Augmentin) for treatment of a variety of bacterial infections, where it prevents antibiotic inactivation by microbial lactamases.