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54-62-6 Aminopterin CAS NO.54-62-6
- FOB Price: USD: 500.00-500.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T
- Available Specifications:
A(10-15)Kilogram
- Product Details
Keywords
- 54-62-6 Aminopterin
- 54-62-6 Aminopterin
- 54-62-6 Aminopterin
Quick Details
- ProName: 54-62-6 Aminopterin
- CasNo: 54-62-6
- Molecular Formula: C19H20N8O5
- Appearance: Solid
- Application: Organic Chemicals
- DeliveryTime: according to client's demand quantity
- PackAge: as requested
- Port: SHANGHAI
- ProductionCapacity: 100 Metric Ton/Day
- Purity: 99%
- Storage: room temperature
- Transportation: by sea
- LimitNum: 1 Kilogram
- Heavy metal: 10ppm
- Grade: Industrial Grade,Pharma Grade
- Transportation: LCL
Superiority
Product Name: Aminopterin
Synonyms: nsc739;AMINOPTERIN;AMINOPTERINE;4-AMINO-PGA;4-AMINOFOLIC ACID;4-AMINOPTEROYLGLUTAMIC ACID;4-AMINOPTEROYL-L-GLUTAMIC ACID;(S)-2-{4-[2,4-diaMinopteridin-6yl)MethylaMino]benzoaMido}pentanedioic acid
CAS: 54-62-6
MF: C19H20N8O5
MW: 440.41
EINECS: 200-209-9
Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Aromatics;Inhibitors
Mol File: 54-62-6.mol
Aminopterin Chemical Properties
Melting point 228-235 °C (dec.)
alpha 18 º (c=1% in 0.1N NaOH)
Boiling point 551.67°C (rough estimate)
density 1.4378 (rough estimate)
refractive index 1.6910 (estimate)
Fp 87℃
storage temp. 2-8°C
solubility 2 M NaOH: 50 mg/mL
pka pKa 5.5 (Uncertain)
form powder
color yellow
Merck 14,472
BRN 69045
CAS DataBase Reference 54-62-6(CAS DataBase Reference)
EPA Substance Registry System Aminopterin (54-62-6)
Safety Information
Hazard Codes T+
Risk Statements 61-28-63-26/27/28
Safety Statements 53-28-36/37-45-36/37/39-22
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS MA1050000
F 8-10-23
HazardClass 6.1(a)
PackingGroup I
HS Code 29339900
Hazardous Substances Data 54-62-6(Hazardous Substances Data)
Toxicity LDLo orl-rat: 2500 mg/kg JPETAB 95,303,49
Aminopterin Usage And Synthesis
Chemical Properties Dark Yellow Solid
Chemical Properties Aminopterin is a white to yellow powder; commonly used as the dihydrate which forms clustersof yellow needles
Uses A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
Uses antineoplastic, antirheumatic, folic acid antagonist
Definition Differs slightly in structure from folic acid and antagonizes the utilization of folic acid by the body, an antimetabolite.
General Description Clusters of yellow needles. Used as a rodenticide, medicine and rodenticide. Not registered as a rodenticide in the U.S.
Health Hazard An antimetabolite; antagonizes the utilization of folic acid by the body. Highly toxic by ingestion.
Details
Product Name: Aminopterin
Synonyms: nsc739;AMINOPTERIN;AMINOPTERINE;4-AMINO-PGA;4-AMINOFOLIC ACID;4-AMINOPTEROYLGLUTAMIC ACID;4-AMINOPTEROYL-L-GLUTAMIC ACID;(S)-2-{4-[2,4-diaMinopteridin-6yl)MethylaMino]benzoaMido}pentanedioic acid
CAS: 54-62-6
MF: C19H20N8O5
MW: 440.41
EINECS: 200-209-9
Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Aromatics;Inhibitors
Mol File: 54-62-6.mol
Aminopterin Chemical Properties
Melting point 228-235 °C (dec.)
alpha 18 º (c=1% in 0.1N NaOH)
Boiling point 551.67°C (rough estimate)
density 1.4378 (rough estimate)
refractive index 1.6910 (estimate)
Fp 87℃
storage temp. 2-8°C
solubility 2 M NaOH: 50 mg/mL
pka pKa 5.5 (Uncertain)
form powder
color yellow
Merck 14,472
BRN 69045
CAS DataBase Reference 54-62-6(CAS DataBase Reference)
EPA Substance Registry System Aminopterin (54-62-6)
Safety Information
Hazard Codes T+
Risk Statements 61-28-63-26/27/28
Safety Statements 53-28-36/37-45-36/37/39-22
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS MA1050000
F 8-10-23
HazardClass 6.1(a)
PackingGroup I
HS Code 29339900
Hazardous Substances Data 54-62-6(Hazardous Substances Data)
Toxicity LDLo orl-rat: 2500 mg/kg JPETAB 95,303,49
Aminopterin Usage And Synthesis
Chemical Properties Dark Yellow Solid
Chemical Properties Aminopterin is a white to yellow powder; commonly used as the dihydrate which forms clustersof yellow needles
Uses A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
Uses antineoplastic, antirheumatic, folic acid antagonist
Definition Differs slightly in structure from folic acid and antagonizes the utilization of folic acid by the body, an antimetabolite.
General Description Clusters of yellow needles. Used as a rodenticide, medicine and rodenticide. Not registered as a rodenticide in the U.S.
Health Hazard An antimetabolite; antagonizes the utilization of folic acid by the body. Highly toxic by ingestion.