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Dicyclohexylcarbodiimide Basic information
Product Name: Dicyclohexylcarbodiimide
Synonyms: Carbodicyclohexylimide;Carbodiimide, dicyclohexyl-;Dicyclimide;dicyclohexyl-carbodiimid;n,n’-dicyclohexylcarbodiimide,1msol.inn-methylpyrrolidone,peptidesynthesisgrade;n,n’-methanetetraylbis-cyclohexaamin;n,n’-methanetetraylbis-cyclohexanamin;N,N’-methanetetraylbis-Cyclohexanamine
CAS: 538-75-0
MF: C13H22N2
MW: 206.33
EINECS: 208-704-1
Product Categories: Pharmaceutical Intermediates;Amino Acid Derivatives;Starting Raw Materials & Intermediates;Miscellaneous;Organics;Coupling Reagent;Peptide Coupling Reagents;Condensing Agents (DNA / RNA Synthesis);Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Nucleosides, Nucleotides & Related Reagents;Peptide Synthesis;Protecting Agents, Phosphorylating Agents & Condensing Agents;Reagents for Oligosaccharide Synthesis;Synthetic Organic Chemistry;Peptide;Protected Amino Acids;Synthetic Reagents;CarbodiimidesSynthetic Reagents;Carbodiimides;Coupling;Peptide Synthesis;peptides;Zero-Length Crosslinker
Mol File: 538-75-0.mol
Dicyclohexylcarbodiimide Structure
Dicyclohexylcarbodiimide Chemical Properties
mp  34-35 °C(lit.)
bp  122-124 °C6 mm Hg(lit.)
density  1.247 g/mL at 25 °C
refractive index  n20/D 1.48
Fp  190 °F
storage temp.  Store at RT.
solubility  methylene chloride: 0.1 g/mL, clear, colorless
Water Solubility  Reaction
Sensitive  Moisture Sensitive
Merck  14,3096
BRN  610662
Stability: Stable, but moisture sensitive. Combustible. Incompatible with strong oxidizing agents. Avoid exposure to air or moisture.
CAS DataBase Reference 538-75-0(CAS DataBase Reference)
NIST Chemistry Reference Methanediimine, n,n'-dicyclohexyl-(538-75-0)
EPA Substance Registry System Cyclohexanamine, N,N'-methanetetraylbis- (538-75-0)
Safety Information
Hazard Codes  T,Xn,T+
Risk Statements  23/24/25-34-40-43-41-36/38-21-24-22-62-37/38-10-61-26-38-20/22
Safety Statements  26-36/37/39-45-41-24-37/39-24/25-36-16-53-28
RIDADR  UN 2922 8/PG 2
WGK Germany  3
RTECS  FF2160000
F  3-8-10-21
HazardClass  6.1
PackingGroup  II
HS Code  29252000
MSDS Information
Provider Language
SigmaAldrich English
ACROS English
ALFA English
Dicyclohexylcarbodiimide Usage And Synthesis
Chemical Properties Colorless solid
Usage This product is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature. This product can also be used in synthesis of peptide and nucleic acid. It is easy to use this product to react with compound of free carboxy and amino-group into peptide. This product is widely used in medical, health, make-up and biological products, and other synthetic fields.
Usage N,N'-Dicyclohexylcarbodiimide is a carbodiimide used to couple amino acids during peptide synthesis. N,N'-Dicyclohexylcarbodiimide is used as a dehydrating agent for the preparation of amides, ketones , nitriles as well as in the inversion and esterification of secondary alcohols.
Usage dicyclohexylcarbodiimide is used as a dehydrating agent at room temperature after a short reaction time, after the reaction product is dicyclohexylurea. the product is very small solubility in an organic solvent, so that easy separation of the reaction product.
General Description White crystalline solid with a heavy sweet odor.
Air & Water Reactions Sensitive to moisture.
Reactivity Profile Dicyclohexylcarbodiimide is an imide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Dicyclohexylcarbodiimide is incompatible with acids and oxidizing agents. Dicyclohexylcarbodiimide reacts with water.
Fire Hazard Dicyclohexylcarbodiimide is probably combustible.
Dicyclohexylcarbodiimide Preparation Products And Raw materials
Preparation Products (S)-3-Aminoquinuclidine dihydrochloride-->Enalapril-->GLY-7-AMINO-4-METHYLCOUMARIN-->2-CYANOPYRIDINE-4-CARBOXALDEHYDE-->H-BETA-ALA-OTBU HCL-->NAPHTHOL AS-BI PHOSPHATE-->Captopril-->2,6-DICHLOROPHENETHYLISOCYANIDE-->1-(2-ISOCYANO-ETHYL)-4-METHYL-PIPERAZINE-->TERT-BUTYL METHYL MALONATE-->Isobutyric anhydride-->Lisinopril-->2-MORPHOLINOISONICOTINALDEHYDE-->1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino] acetyl] amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl]methyl]pyridinum hydroxide inner salt-->7-DIETHYLAMINO-3-THENOYLCOUMARIN-->Cefprozil hydrate-->4-ISOCYANOBENZOPHENONE-->TERT-BUTYL 3-HYDROXYPROPIONATE-->Docetaxel-->Cyclic AMP-->ANGIOTENSIN II, HUMAN-->3-CARBETHOXY-4-HYDROXYCOUMARIN-->7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid-->Beraprost-->Octreotide acetate-->Trandolapril-->Tetrabenzyl pyrophosphate-->Paroxetine-->Benexate Hydrochloride-->IBUTILIDE-->Latanoprost
Raw materials Azabenzene-->Urea-->Carbon disulphide-->Cyclohexylamine-->DCHA-->N,N'-DICYCLOHEXYLUREA-->1,3-Dicyclohexylthiourea