Isopropyl (4-chlorophenyl) acetyl chloride

English Synonyms: 3-methyl-2- (4-chlorophenyl) butyryl chloride; 2- (4-chlorophenyl) (4-CHLOROPHENYL) -3-METHYLBUTYRYL; Alpha-Isopropyl-4-Chlorophenyl Acetyl Chloride; 2- (4-CHLOROPHENYL) -3-METHYLBUTYL CHLORID;

CAS number: 51631-50-6

Molecular formula: C11H12Cl2O

Molecular weight: 231.11838

EINECS number:

Related Articles: Acid Halides; Carbonyl Compounds; Organic Building Blocks; Pyrethroid Insecticides; Pesticide Intermediates; Insecticide Intermediates; Halides;

Mol file: 51631-50-6.mol

3-Methyl-2- (4-chlorophenyl) butyryl chloride

3-Methyl-2- (4-chlorophenyl) butyryl chloride Properties

Boiling point 124-130 ° C (3 Torr)

Density 1.171 g / mL at 25 ° C (lit.)

Refractive index n20 / D 1.526 (lit.)

Flash point> 230 ° F

3-methyl-2- (4-chlorophenyl) butyryl chloride Use and synthesis method

Chemical properties 3-methyl-2- (4-chlorophenyl) butyryl chloride pure colorless liquid, bp102 ~ 104 ℃ / 80pa, industrial products for the red-brown oily liquid, irritating odor, dissolved in organic solvents , Easy to absorb moisture decomposition.

Use 3-methyl-2- (4-chlorophenyl) butyryl chloride is an important intermediate for the preparation of fenvalerate, viologen and fenvalerate.

Use pesticide intermediates.

Production methods α-isopropyl p-chlorophenylacetic acid obtained by chlorination. The α-isopropyl p-chlorophenylacetic acid and phosphorus pentachloride were mixed at a molar ratio of 1: 1.1, heated to 130 ° C. with stirring, and reacted at 130-140 ° C. for 1 hour. Cooling generated by the exclusion of hydrogen chloride, steamed phosphorus oxychloride by-product, vacuum distillation, collecting 100-103 ° C (0.4-0.47kPa) distillate, that was α-isopropyl p-chlorophenylacetyl chloride, the content of 95 % Or more, yield 95% or more.

Production methods The preparation of the following methods.

Phosgene Act

3-methyl-2- (4-chlorophenyl) butanoic acid was put into the reaction kettle, and a small amount of DMF was used as a catalyst. After the temperature was raised to melt the solid, a small amount of phosgene was started and the temperature was controlled at 80-90 ° C, Gradually increase the amount of phosgene access, when the phosgene access reaches a certain amount, the reaction temperature was reduced to 50 ~ 60 ° C, and then into the phosgene, phosgene to reach the required amount, stop phosgene 60 ~ 70 ℃ through the gas to catch gas, phosgene rush out after the discharge, as the finished product.

Thionyl chloride method

Thionyl chloride was put into the reaction kettle and the temperature was raised to 30 to 40 ° C. 3-Methyl-2- (4-chlorophenyl) butanoic acid in a molten state was added dropwise. After the addition was completed, the mixture was incubated at 30 to 40 ° C for 0.5 h, after the reaction, the excess pressure to take off thionyl chloride, cooling the finished product obtained.