Fusidine Basic information
Mode of action
Product Name: Fusidine
Synonyms: 29-NordaMMara-17(20),24-dien-21-oicacid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-;Fusidic acid for peak identification;(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid;-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H);-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S);-6-methylhept-5-enoic acid;29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-;Fusidic acid, 98.5%
CAS: 6990-06-3
MF: C31H48O6
MW: 516.71
EINECS: 230-256-0
Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;E-FCell Signaling and Neuroscience;Gene Regulation and Expression;RNA-Protein Translation Inhibitors;Stains and Dyes;Stains&Dyes, A to;API;FUCIDINE;antibiotic
Mol File: 6990-06-3.mol

Fusidine Chemical Properties
Melting point  190-192°C
alpha  D20 -9° (chloroform)
Boiling point  521.49°C (rough estimate)
density  1.0389 (rough estimate)
refractive index  1.4890 (estimate)
storage temp.  2-8°C
solubility  Practically insoluble in water, freely soluble in ethanol (96 per cent)
form  neat
pka pK: 5.35 in water
λmax 204nm(H2O)(lit.)
Merck  14,4317
CAS DataBase Reference 6990-06-3(CAS DataBase Reference)

Fusidine Usage And Synthesis
Mode of action Fusidic acid forms a stable complex with an elongation factor (EF-G) involved in translocation and with guanosine triphosphate (GTP), which provides energy for the translocation process. One round of translocation occurs, with hydrolysis of GTP, but the fusidic acid–EF-G–GDP complex cannot dissociate from the ribosome, thereby blocking further chain elongation and leaving peptidyl-tRNA in the P site.
Although protein synthesis in Gram-negative bacilli–and, indeed, mammalian cells–is susceptible to fusidic acid, the antibiotic penetrates poorly into these cells and the spectrum of action is virtually restricted to Gram-positive bacteria, notably staphylococci.
Chemical Properties White Solid
Uses Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.
Uses antibacterial
Definition ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.
Brand name Fucidine (Bristol-Myers Squibb).
Hazard Moderately toxic inhibitor of translocation during protein synthesis.