Fluocinolone acetonide

English Synonyms: (6-alpha, 11-beta, 16-alpha) -idene) bis (oxy)); (6alpha, 11beta, 16alpha) -idene) bis -11,12-dihydroxy-16,17 - (1-methylethylidene) bis (oxy)) -, 6-alpha, -alpha-hydroxyprednisolone 16,17-acetonide; 6alpha, 9alpha-difluoro-16alpha-hydroxyprednisolone 16,17-acetonide; dermalar; fluocinolone 16,17-acetonide; Fluocinoloneacetate

CAS number: 67-73-2

Molecular formula: C24H30F2O6

Molecular weight: 452.49

EINECS No. 200-668-5

Related Categories: Organics; Alkaloids; Biochemistry; Quinoline Alkaloids; Intermediates & Fine Chemicals; Pharmaceuticals; Steroids; APIs; Steroid Hormones; Hormone Drugs; Steroid Hormones; Intermediates; Steroids Class; small molecule inhibitors; pharmaceutical raw materials; organic silicon compounds; other

Mol file: 67-73-2.mol

Vinegar skin easily

Vinegar skin relaxed nature

Melting point 267-269 ° C (lit.)

Specific rotation D + 95 ° (chloroform)

Refractive index 103 ° (C = 1, MeOH)

Storage conditions

Soluble in water (partly), DMSO, alcohol, chloroform and methanol.

Merck 4150

CAS Database 67-73-2 (CAS DataBase Reference)

EPA chemical information Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy- 16,17 - [(1-methylethylidene) bis (oxy)] - alpha., 11.beta., 16.alpha.) - (67-73-2)

Vinegar easy to use and synthetic methods

Corticosteroids, acetic acid skin easily, also known as fluocinonide acetate, fluoxetine, dextromethorphan, skin easily flu, easily flu, Sin Nile, acetonide fluoride new dragon, for the efficacy of topical corticosteroids in our country the most significant Smaller side effects, can make the dermal capillaries shrink, inhibit the proliferation of connective tissue cells or regeneration; also stabilize intracellular lysosomal membrane, prevent intracellular lysosomal enzymes release histamine and cause tissue damage. The anti-inflammatory effect of hydrocortisone 100 times, the use of the minimum concentration (0.025%) that has significant efficacy, and rapid response, can significantly reduce or cure within a few days, itching better. Cortexic acid is mainly used for skin diseases that are effective for glucocorticoids such as contact dermatitis, atopic dermatitis, seborrheic dermatitis, neurodermatitis, solar dermatitis, eczema (especially infant eczema), itchy skin Disease, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa and so on. Compatibility with neomycin and other antibiotics can treat suppurative skin diseases. To 0.025-0.05% ointment, lotion applied to the affected area, 2-3 times daily, gently rub it to penetrate the skin.

Physical and chemical properties of white or almost white crystalline powder, odorless, tasteless. [α] D20 +80 - +88 ° (dioxane). Soluble in acetone, slightly soluble in ethanol, dioxane, insoluble in water, petroleum ether. By 11α-hydroxy-16α, 17α-epoxyprosten-4-ene-3,20-dione by sulfo esterification, ring-opening and other 16-step reaction derived. For allergic dermatitis, contact dermatitis, eczema and other skin diseases.

Fluocinolone acetate fluocinolone is a synthetic, fluorine-containing steroid. Topical can make dermal capillaries shrink, inhibit the proliferation of epidermal cells or regeneration, inhibition of knot tissue fibroblast newborn, stable intracellular lysosomal membrane, with anti-inflammatory, itching effect. After external use can be absorbed through the intact skin. After absorption and systemic administration of corticosteroids in vivo metabolism, mainly in the liver metabolism, excretion by the kidneys. Fluocinolone acetate is suitable for dermatoses that are effective on corticosteroids such as eczema (especially infant eczema), neurodermatitis, pruritus, contact dermatitis, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa, Dermatitis and so on. But need to pay attention to long-term or large-scale use can cause skin atrophy, telangiectasia, the occurrence of acne-like dermatitis, perioral dermatitis, folliculitis, increased susceptibility to infection. Even can cause allergic contact dermatitis.

Use for allergic dermatitis, contact dermatitis, seborrheic dermatitis and eczema.

Use for the treatment of eczema, neurodermatitis, pruritus, contact dermatitis, psoriasis, solar dermatitis and other diseases