Azamethiphos

English Synonyms: Alfracron; GS 40616; O-dimethyl-S- [6-chloro-2- oxooxazolo [4,5-b] pyridin- dimethoxyphosphorylsulfanylmethyl- [1,3] oxazolo [4,5-b] pyridin-2-one; Phosphorothioic acid, S - [(6-chloro-2- oxooxazolo [4,5-b] yl) methyl] O, O-dimethyl ester; Thiophosphoric acid S- (6-chloro-2-oxo-2,3- dihydrooxazolo [4,5-b] acid S - [6-chloro-2-oxooxazolo [4,5-b] pyridin-3 (2H) -yl) methyl] O, O-dimethyl ester; Azamethiphos 100 ug / ml in Methylene chloride 5 ml [35575-96- 3]

CAS number: 35575-96-3

Molecular formula: C9H10ClN2O5PS

Molecular weight: 324.68

EINECS No. 252-626-0

Related Categories: Agro Products; Agro-Products; Phosphorylating and Phosphotropiclating Agents; AR to AZ Pesticides; A; A-BAlphabetic; Alpha sort; Insecticides; Organophorous; Pesticides & Metabolites; Alphabetic; Pesticides; Insecticides (Mites); Organophosphorus Insecticides ; Pyridine; Analytical standards; Chemical raw materials; Organochlorine pesticides; Insecticides; Feed additives; Pesticide intermediates; Pesticide & intermediate; Pesticide and its intermediates

Mol File: 35575-96-3.mol

Pyridoxine

Pyrazolidine P Properties

Melting point 88-93 ° C

Storage conditions APPROX 4 ° C

Form Solid

CAS Database 35575-96-3 (CAS DataBase Reference)

NIST chemical information Phosphorothioic acid, s - [(6-chloro-2-oxooxazolo [4,5-b] pyridin-3 (2h)

EPA chemical information Phosphorothioic acid, S - [(6-chloro-2-oxooxazolo [4,5-b] pyridin-3 (2H)

Adoption and synthesis of

Organic phosphorus insecticide Pyridoxine, also known as methyl pyridine phosphorus, is an organophosphorus insecticide, white or almost white crystalline powder, there are offensive odor, slightly soluble in water, soluble in methanol, methylene chloride Other organic solvents. Used to kill livestock, flies and other birds house bloodsucking insects. Excipients are added exogenous agents in the fly, traps on the trapping effect, for spray or coating.

This product is a high efficiency, low toxicity of new organophosphate pesticides. Mainly to stomach poisoning, both touch action, killing flies, cockroaches, ants and some insects adult. Because these adult insects have a habit of licking their stomachs, the drug acting through stomach poisoning works better. As with the attractant, can increase the ability to induce flies 2 to 3 times. According to the required concentration of one-time spray, the reduction rate of flies up to 84% to 97%. Methyl pyridine phosphorus also has a long period of residual characteristics. Apply it to paperboard, hang on the house or on the wall, the residual validity of up to 10 to 12 weeks, sprayed on the wall ceiling residual effect of 6 to 8 weeks.

After ingestion of oxacillin, animals almost completely absorbed. Twelve hours after oral administration of the goat, the drug was excreted 76% of the urine, 5% of the excrement, and 0.5% of the milk. The residue in the tissue was low, the muscle was 0.022mg / kg, the kidney was 0.14 ~ 0.4mg / kg; the hen took the 5mg / kg medicated feed, the residue after 22 hours, the blood was 0.1mg / kg, the kidney was 0.6mg / kg. Thus, the medicine in the meat, fat, eggs, very few residues, without prescription withdrawal period. In addition to this product into the adult, the cockroaches, ants, fleas, bugs, also have a good killing effect. Mainly used to kill the stalls, chicken coops and other places into the flies; also used in homes, restaurants, food factories and other places to fly, kill cockroaches.

Toxic rats acute oral LD50 1180mg / kg, rats acute percutaneous LD50> 2150mg / kg. Rabbit eyes mild irritation, no irritation to the skin. The 90-day feeding test in rats showed no effect dose of 20mg / kg feed, the dog was 10mg / kg (0.3mg / kg per day). LC50 of rainbow trout is 0.2mg / L, carp LC50 is 6.0mg / kg, gill fish LC50 is 8.0mg / L (both 96h), low toxicity to birds, toxic to bees.

Pure chemical nature of colorless crystals. m.p. 89 ° C, vapor pressure 0.0049 × 10 -3 Pa (20 ° C). Solubility at 20 ° C: Benzene 13g / L, Methanol 10g / kg, Methylene chloride 6.1g / kg, Water 1.1g / kg. The half-life of hydrolysis reaction at 20 ℃ is 800h (pH 5), 260h (pH 7) and 4.3h (pH 8).

Use insecticide, acaricide. With contact and stomach poisoning effect, good effect. The pesticide is broad in spectrum and can be used for controlling various mites and codling moths, aphids, leafhoppers, psyllids, gall beetles, potato beetles and cockroaches in cotton, fruit trees, vegetable fields and livestock herds, families and public places. The dosage 0.56 ~ 1.12kg / hm2.

Use can effectively kill flies, ants, cockroaches and other pests

Production Method Preparation of N-hydroxymethyloxazolo [4,5-b] pyridin-3- (2H) one A mixture of 109 g of oxazolo [4,5-b] Formaldehyde aqueous solution is methylolated at 50-60 ° C to give 126 g of N-hydroxymethyloxazolo [4,5-b] pyridin-3- (2H) one.

Preparation of N-chloromethyloxazolo [4,5-b] pyridin-3- (2H) one The N-hydroxymethyloxazolo [4,5-b] (2H) one was chlorinated with thionyl chloride at 60 ° C to obtain 125 g of N-chloromethyloxazolo [4,5-b] pyridin-3- (2H) one.

Methylpyrazole The N-chloromethyloxazolo [4,5-b] pyridin-3- (2H) one obtained in the previous step was reacted with O, O-dimethylthiophosphoric acid ammonium salt [ (CH3O) 2P (O) SNH4] role in the preparation of methyl pyrophosphate.

Category Pesticides

Toxicity grade poisoning

Acute Toxicity Oral - Rat LD50; 1180 mg / kg; Skin - Rat LD50: 2150 mg / kg

Combustible Hazardous Characteristics Combustible; Combustion produces toxic oxides of nitrogen, sulfur oxides, phosphorus oxides and chlorinated fumes

Storage and transportation characteristics of ventilation and low temperature drying

Extinguishing agent dry powder, foam, sand, carbon dioxide, water mist