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MONOCROTALINE CAS NO.315-22-0
- FOB Price: USD: 1.00-1.00 /Metric Ton Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,T/T,
- Available Specifications:
Best Quality(1-20)Metric Ton
- Product Details
Keywords
- MONOCROTALINE
- high purity MONOCROTALINE
- factory supply MONOCROTALINE
Quick Details
- ProName: MONOCROTALINE
- CasNo: 315-22-0
- Molecular Formula: C16H23NO6
- Appearance: White to light tan powder
- Application: Pharmaceutical intermediates
- DeliveryTime: in stock
- PackAge: as you requested
- Port: China main port
- ProductionCapacity: 10 Kilogram/Day
- Purity: 99% min
- Storage: Room temperature
- Transportation: by courier
- LimitNum: 1 Gram
- Transportation: by courier
Superiority
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:
1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
Our advantage:
1. Higest quality and good package
2.Fast delivery
3.Better payment term
4.Fast response to customer within 6 hours
5.Good business credit in Europe ,US ,Japan ,Korea
Anyway ,if you need any chemicals from China ,Henan Tianfu can help you
Details
| Product Name: | MONOCROTALINE |
| Synonyms: | MONOCROTALIN;MONOCROTALINE;CROTALIN;CROTALINE;(13-alpha,14-alpha)-14,19-dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dio;(13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione;(2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihy;(2,3,4-gh)pyrrolizine-2,6(3H)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-(1,6)dioxacycloundecino- |
| CAS: | 315-22-0 |
| MF: | C16H23NO6 |
| MW: | 325.36 |
| EINECS: | 2017-001-1 |
| Product Categories: | Miscellaneous Natural Products;Amines;Heterocycles;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors |
| Mol File: | 315-22-0.mol |
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| MONOCROTALINE Chemical Properties |
| Melting point | 204 °C (dec.)(lit.) |
| alpha | -54.8o (C=5 IN CHLOROFORM) |
| storage temp. | 2-8°C |
| Merck | 13,6274 |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 25-40-35 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 1544 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | QB3140000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ACROS | English |
| MONOCROTALINE Usage And Synthesis |
| Description |
Monocrotaline (MCT) is a toxic 11-membered macrocyclic pyrrolizidine alkaloid (PA) derived from the seeds of the Crotalaria spectabilis plant. It poisons livestock and humans through the ingestion of contaminated grains and other foods. Pyrrolizidine alkaloid is activated by cytochrome P450 to the reactive pyrrole metabolite dehydromonocrotaline (MCTP) in the liver. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Monocrotaline is produced for research use. It is used in rat model to investigate human pulmonary hypertension as it offers technical simplicity, reproducibility, and low cost compared with other models of pulmonary hypertension. |
| References |
[1] Jose G. Gomez-Arroyo, Laszlo Farkas, Aysar A. Alhussaini, Daniela Farkas, Donatas Kraskauskas, Norbert F. Voelkel, Harm J. Bogaard (2012) The monocrotaline model of pulmonary hypertension in perspective, Am J Physio Lung Cell Mol Phyisol, 302, L363-L369 [2] # |
| Chemical Properties | White to light tan powder |
| Uses | A toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats. |
| Uses | antineoplastic, insect sterilant |