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Product Name: Flumethasone
Synonyms: CORTEXILAR;FLUCORT;FLUMETHASONE;ANIPRIME;6a,9a-difluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione;6a,9a-difluoro-16a-methylprednisolone;6A-FLUORO-DEXAMETHASONE;6ALPHA,9ALPHA-DIFLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE
CAS: 2135-17-3
MF: C22H28F2O5
MW: 410.45
EINECS: 218-370-9
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;FLUCORT;Hormone Drugs
Mol File: 2135-17-3.mol
Flumethasone Structure
Flumethasone Chemical Properties
Melting point  237-240°C
storage temp.  2-8°C
solubility  acetic acid: soluble10mg/mL
color  white
Merck  14,4138
CAS DataBase Reference 2135-17-3(CAS DataBase Reference)
Safety Information
Hazard Codes  Xn
Risk Statements  40
Safety Statements  22-36
WGK Germany  3
RTECS  TU3832000

Flumethasone Usage And Synthesis
Description Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. Its mechanism of action is thought to inhibit arachidonic acids role in the biosynthesis of prostaglandins and leukotrienes. Flumethasone is active when it is not bound to the plasma protein transcortin. The drug flumethasone can be used to treat a variety of skin conditions, such as contact dermatitis, bug bites and eczema.
Uses
Flumethasone is an anti-inflammatory glucocorticoid used in veterinary practice and used as an anti-inflammatory for a variety of animals. It is commonly investigated for its effectiveness in animals to combat inflammatory symptoms caused by pathogens and to better understand inflammatory mechanisms. It is also used as to investigate novel techniques that detect and quantify steroid compounds within muscles.
For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions.
Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity.
Flumethasone has been shown to exert anti-inflammtory effects by functioning as a glucocorticoid receptor agonist. Stimulating this receptor promotes inhibition of phospholipase A2 activity. This enzyme catalyzes arachidonic acid into eicosanoids most of which stimulate anti-inflammation mechanisms.
Application
Flumethasone is a topical corticosteroid of the glucocorticoid class used in the treatment of skin disorders where it reduces inflammation.
Flumethasone is insoluble in water.
Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application.
It is commonly used in veterinary practice and has been used in cortisol assays to study early porcine conceptus development.
Biological Activity Flumethasone pivalate is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activations and repressions. The anti-inflammatory action of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Chemical Properties White Solid
Uses topical anti-inflammatory corticosteroid
Uses A glucocorticoid. An anti-inflammatory