Anti-gram-positive bacteria are similar with ciprofloxacin. The anti-Gram-negative bacteria, led by pseudomonas aeruginosa, is better than the similar products, such as ciprofloxacin, ofloxacin, levofloxacin, resistance to green pus bacillus particularly high sensitivity, and the antibacterial abilitu is better than the gatifloxacin class and other antibiotics currently listed.

The oral absorption is good without savings and cerebrospinal fluid distribution,  and the side effects is little.

The half-life is as long as 8-9 hours, and the number of eating medication is few.

Rapid onset, time to peak within 0.5 to 1 hour, the effet is stronger (due to bacterial accumulation in good).

IndicationIt is used for the treatment of prulifloxacin sensitive staphylococcus, streptococcus, Neisseria gonorrhoeae, (except typhoid, paratyphoid) pneumoniae, Enterococcus, Moraxella Alex Salmonella, E. coli, Shigella, Salmonella, lemon acid bacteria, Klebsiella pneumoniae, Serratia, Proteus, Vibrio cholerae, Pseudomonas aeruginosa, Streptococcus digestion, they can cause the following infections:

 

Superficial skin infections (acute superficial folliculitis, infectious impetigo), deep skin infections (cellulitis, erysipelas, boils, boils swollen disease, appendicitis, suppurative paronychia), chronic pyoderma (sebaceous cyst infection, purulent, etc.).

Superficial secondary infections, such as abscess, trauma, burns, and surgical trauma.

Acute respiratory infections (pharyngitis, tonsillitis, acute bronchitis), chronic respiratory disease secondary infection (chronic bronchitis, diffuse bronchiolitis, bronchiectasis, emphysema, pulmonary fibrosis, bronchial asthma, etc.) and pneumonia.

Cystitis, pyelonephritis, prostatitis.

Cholecystitis, cholangitis.

Infectious enteritis, bacillary dysentery, salmonellosis, cholera.

The uterine infection, adnexitis.

Blepharitis, stye.

Otitis media, sinusitis.

PharmacokineticsAfter oral administration, Prulifloxacin is rapidly metabolized as an active form of drug, Ulifloxacin. The drug exerts good penetration into the target tissue with prolonged elimination half-life with once-daily administration. 

After absorption, Cmax is generally achieved within one hour, and apparent Vss is 1231 L. About 45% of the administered drug is bound to plasma proteins. The drug is extensively metabolized by first-pass metabolism into active metabolites. The terminal half-life of Ulifloxacin is 10.6-12.1 hours. The drug is mainly excreted via the urine as unmetabolized drug.Prulifloxacin IntermediatePrulifloxacin Intermediate PL-7

Appearance: white to light yellow powder

Chemical name: 6,7-difluoro-2-mercapto-ethyl-4-hydroxy-quinoline-3-carboxylic acid ethyl ester CAS: 154330-68-4

 Molecular Formula: C14H13F2NO3S

Prulifloxacin intermediate PL-9

Appearance: white to light yellow powder

Chemical name: 6,7-difluoro-1-methyl-4-oxo--4H-(1,3) thiazine (3,2a) and quinoline-3-carboxylate CAS: 113046-72-

Molecular Formula:C14H11F2NO3S

Prulifloxacin Intermediate PL-10

Appearance: white to light yellow powder

Chemical Name: 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl) 4H-(1,3) thiazine (3,2a) and quinoline-3-carboxylate CAS: 113028-17-4

 Molecular Formula:C18H20FN3O3S

Prulifloxacin Intermediate PL-11

Appearance: white to light yellow powder

Chemical Name: 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3) thiazine (3,2a) and quinoline-3-carboxylic acid CAS : 112984-60-8

Molecular Formula:C16H16FN3O3S

Application:For the total synthesis of gatifloxacin antibacterialsSide effectsAbdominal cramp, Confusion, Diarrhoea, Drowsiness, Altered taste, Epigastric pain, Gastritis, Headache, Hot flashes, Increased bilirubin in the blood, Itching, Loss of appetite, Sedation, Skin rash, Sleep disorder, Vomiting, Nausea.Referenceshttps://www.ncbi.nlm.nih.gov/pubmed/15456336

# PropertiesOff-White SolidUsesPrulifloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Prulifloxacin is a prodrug for active metabolite, Ulifloxacin. Antibacterial.UsesFluoroquinoline antibacterial; prodrug for active metabolite, Ulifloxacin. Antibacterial.