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Ruxolitinib phosphate Basic information
Product Name: Ruxolitinib phosphate
Synonyms: (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate;INCB 018424;Ruxolitinib, Phosphate Salt;Ruxolitinib, Phosphate;(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazole-1-propanenitrile Phosphate;INCB 018424(Ruxolitinib Phosphate);INCB 018424 (phosphate);INCB018424 (phosphate)
CAS: 1092939-17-7
MF: C17H18N6.H3PO4
MW: 404.360201
EINECS:
Product Categories: Intracellular signaling.;Antineoplastic;Inhibitors
Mol File: 1092939-17-7.mol

Ruxolitinib phosphate Usage And Synthesis

Uses The phosphate salt of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.

Definition ChEBI: A phosphate salt obtained by reaction ruxolitinib with one equivalent of phosphoric acid. Used for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essent al thrombocythemia myelofibrosis.