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Product Name: Tilmicosin
Synonyms: 20-DEOXO-20-(3,5-DIMETHYL-1-PIPERIDINYL)DESMYCOSIN;TILMICOSIN;Tilmicosin, Vetranal;Tilmicosine;Tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-.alpha.-L-ribo-hexopyranosyl)-20-deoxo-20-(3R,5S)-3,5-dimethyl-1-piperidinyl-;pulmotil;4A-O-De(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]tylosin;Antibiotic EL 870
CAS: 108050-54-0
MF: C46H80N2O13
MW: 869.13
EINECS:
Product Categories: Active Pharmaceutical Ingredients;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;API
Mol File: 108050-54-0.mol
Tilmicosin Structure
Tilmicosin Chemical Properties
alpha  D23 +12.75° (c = 0.010004 in CHCl3, 5 cm)
storage temp.  0-6°C
pka pKa (66% DMF): 7.4, 8.5(at 25℃)
EPA Substance Registry System Tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-. alpha.-L-ribo-hexopyranosyl)- 20-deoxo-20-[(3R,5S)-3,5- dimethyl-1-piperidinyl]-(108050-54-0)
Safety Information
Hazardous Substances Data 108050-54-0(Hazardous Substances Data)

Tilmicosin Usage And Synthesis
Brief introduction Tilmicosin is a relatively novel semi-synthetic macrolide antibiotics derived from tylosin for being applied to livestock and poultry. The chemical name is 4A-O-de (2, 6-dideoxy-methyl-3-C--L-ribose-pyran-hexyl)-20-deoxy-20-(3,5-dimethyl-1-piperidinyl)-[20 (cis: trans)] tylosin. Molecule formula is C46H80N2O13 and the molecular weight of 869.15.
Tilmicosin has a similar antibacterial spectrum as tylosin but has enhanced effect on the anti-Pasteurella multocida and hemolytic pasteurella. It was successfully developed in 1980s and initially used with a code of EL-870. Common trade names include Pulmotil © Micotil ©, preparations include tilmicosin soluble powder, premix (20%) preparation, and injection. In 1990 it was approved in most European countries; it was approved in the US in 1992, and included in USP. China also has some domestic enterprises approved for production of tilmicosin.
Because of its special antibacterial activity and pharmacokinetic characteristics, the drug has been approved for clinical prevention and treatment of infectious diseases for cattle, goats, sheep, cows, pigs, and chickens. It is especially applied to the treatment of respiratory diseases of livestock, such as cattle Actinobacillus pleuropneumonia, Pasteurella disease, chicken mycoplasmosis and mastitis of lactating animals.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical Properties It is white or white powder with humidity: ≤5.0%.
Uses It can be used as anti-bacterial.
It is mainly used for the treatment of infection caused by pleuropneumonia, Actinobacillus, Pasteurella and mycoplasma.
Chemical Properties White Solid