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Tween 80 Basic information
Description References
Product Name: Tween 80
Synonyms: EMALEX ET-8020;EMALEX ET-8040;FEMA 2917;PEG-3 SORBITAN OLEATE;PEG-6 SORBITAN OLEATE;POLYOXYETHYLENESORBITAN MONOOLEATE*MOLEC ULAR BIOLOG;POLYOXYETHYLENESORBITAN MONOOLEATE*(TWEE N 81);POLYOXYETHYLENESORBITAN MONOOLEATE, LOW PEROXIDE
CAS: 9005-65-6
MF: C24H44O6
MW: 428.600006103516
EINECS: 500-019-9
Product Categories: detergent;Ester Ether Type (Surfactants);Functional Materials;Nonionic Surfactants;Surfactants;Biochemistry;Nonionic Surfactants (for Biochemistry);Surfactants (for Biochemistry);Cosmetic Ingredients & Chemicals;emulsifier
Mol File: Mol File
Tween 80 Structure
Tween 80 Chemical Properties
Boiling point  >100°C
density  1.08 g/mL at 20 °C
vapor pressure  <1 mm Hg ( 20 °C)
refractive index  n20/D 1.473
FEMA  2917 | POLYSORBATE 80
Fp  >230 °F
storage temp.  Store at RT.
form  viscous liquid
color  Amber
Specific Gravity 1.080 (25/4℃)
PH 5-7 (50g/l, H2O, 20℃)
PH Range 6
Water Solubility  5-10 g/100 mL at 23 ºC
Merck  14,7582
Hydrophilic-Lipophilic Balance (HLB) 10
EPA Substance Registry System Polysorbate 80 (9005-65-6)
Safety Information
Hazard Codes  Xi
Risk Statements  22-36/37/38-37/38-41
Safety Statements  24/25-36/37/39-36-26
WGK Germany  1
RTECS  WG2934000
F  3Description Tween 80, commonly known as polysorbate 80, is a synthetic compound that is widely applied in a variety of fields, including foods, medicines, and cosmetics. In food production, it is commonly used as a defoamer for the fermenting process of some wines and as a emulsifier in ice-cream or “puddings” to keep the creamy texture without separating. Tween 80 is also extensively applied in pharmaceutical industry, where it can be found in some vaccines, vitamins and supplements. It is an effective excipient to stabilize aqueous formulations of medications for parenteral administration and to improve the consistency of gel capsules, thus to make pills disperse in the stomach. Besides, it commonly serve as a surfactant and solubilizer in the production of soaps and cosmetics, which is effective to help dissolve ingredients and make products look creamier and more attractive. In laboratory, it is occasionally  used for a test to identify the phenotype of a strain or isolate, such as mycobacteria.
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Chemical Properties Polysorbate 80 has a faint, characteristic odor and a warm, somewhat bitter taste. It is a mixture of oleate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides.
Chemical Properties Yellow to amber liquid
Uses Lonzest(R) SMO-20 is used as an emulsifier for textiles, personal care and industrial applications.
Uses Lonzest(R) SMO-5 is a general purpose mid-range HLB, ethoxylated, nonionic surfactant suggested for use in textile chemicals (emulsifier, lubricant), household products and cosmetic formulations (o/w emulsifier, viscosity modifier).
Uses Glycolube(R) AFA-1 is used as an antistat for PVC and as an antifog for PP, PE, PVC, PS.
Uses Vinylube(R) 38 is an external lubricant for PVC bottle, film, and sheet components with excellent processing abilities and final clarity. It is also used as an antistatic agent. Product Data Sheet
Uses Glycosperse(R) O-20 KFG is used as an emulsifier (ice cream, whipped topping) and as a solubilizing and dispersing agent in pickles and special vitamin-mineral preparations. Product Data Sheet
Uses A non ionic detergent for cell lysis
Uses As emulsifiers and dispersing agents in medicinal products; as defoamers and emulsifiers in foods. Pharmaceutic aid (surfactant).
Definition ChEBI: A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.
Brand name Sorlate (Abbott); Tween 80 (ICI Americas).
General Description Amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and bitter taste.
Air & Water Reactions Water soluble.
Reactivity Profile Tween 80 is incompatible with strong alkalis and oxidizers.
Fire Hazard Tween 80 is probably combustible.
Safety Profile Moderately toxic by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
TSCA  Yes
HS Code  34021300
Hazardous Substances Data 9005-65-6(Hazardous Substances Data)
Toxicity LD50 in mice, rats (ml/kg): 7.5, 6.3 i.p. (Varma)