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In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

Our main business covers the fields below:

1.Noble Metal Catalysts (Pt.Pd...)

2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)

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4.Customs Synthesis

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Acipimox Basic information
Description References
Product Name: Acipimox
Synonyms: 6-Methyl-1-oxo-1$l^{5},4-pyrazine-3-carboxylic acid;AcipiMox-13C2,15N2;2-Carboxy-5-methylpyrazine 4-oxide;ACIPIMOX;5-methylpyrazine-2-carboxylic acid 4-oxide;5-methyl-2-pyrazinecarboxylicaci4-oxide;5-methyl-2-pyrazinecarboxylicacid4-oxide;4-Oxo-5-Methyl-2-Pyrazine-carboxylic Acid
CAS: 51037-30-0
MF: C6H6N2O3
MW: 154.12
EINECS: 256-928-3
Product Categories: Pharmaceuticals;OLBEMOX;Pyrazine;Heterocycles;Intermediates & Fine Chemicals
Mol File: 51037-30-0.mol
Acipimox Structure
Acipimox Chemical Properties
Melting point  177-180 °C
storage temp.  2-8°C
CAS DataBase Reference 51037-30-0(CAS DataBase Reference)
EPA Substance Registry System Pyrazinecarboxylic acid, 5-methyl-, 4-oxide(51037-30-0)
Safety Information
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
RTECS  UQ2453000
MSDS Information
Acipimox Usage And Synthesis
Description Acipimox is a potent long-acting antilipolytic nicotinic acid (NA) analog. Like nicotinic acid, acipimox lowers lipids effectively, but unlike nicotinic acid, acipimox is longer acting and therefore much less prone to produce free fatty acid rebounding.
Acipimox is recommended as a lipid-lowering agent to treat hyperlipidemia in patients with noninsulin dependent diabetes mellitus.
References [1] Ana T.M.G. Santomauro, Guenther Boden, Maria E.R. Silva, Dalva M. Rocha, Rosa F. Santos, Mileni J.M. Ursich, Paula G. Strassmann and Bernardo L. Wajchenberg, Overnight Lowering of Free Fatty Acids With Acipimox Improves Insulin Resistance and Glucose Tolerance in Obese Diabetic and Nondiabetic Subjects, Diabetes, 1999, vol. 48, 1836-1841
[2] K. C. Shih, C. F. Kwok, C. M. Hwu, L. C. Hsiao, S. H. Li, Y. F. Liu, L. T. Ho, Acipimox attenuates hypertriglyceridemia in dyslipidemic noninsulin dependent diabetes mellitus patients without perturbation of insulin sensitivity and glycemic control, Diabetes Research and Clinical Practice, 1997, vol. 36, 113-119
Chemical Properties Yellow Solid
Uses Antilipemic.
Biological Activity Antilipolytic agent; lowers plasma free fatty acid (FFA), triglyceride (TG), glucose and insulin levels and increases leptin levels.
Acipimox Preparation Products And Raw materials
Raw materials Chloroform-->Hydrogen peroxide-->Maleic anhydride -->5-Methyl-2-pyrazinecarboxylic acid