China (Mainland)
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discount Canertinib dihydrochloride CAS NO.289499-45-2
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,T/T,
- Available Specifications:
Best Quality(1-10)Gram
- Product Details
Keywords
- Canertinib dihydrochloride
- high purity Canertinib dihydrochloride
- factory supply Canertinib dihydrochloride
Quick Details
- ProName: discount Canertinib dihydrochloride
- CasNo: 289499-45-2
- Molecular Formula: C24H27Cl3FN5O3
- Appearance: solid
- Application: Pharmaceutical intermediates
- DeliveryTime: With about 7-10 days after receipt the...
- PackAge: as you requested
- Port: china mian port
- ProductionCapacity: 10 Gram/Day
- Purity: 99% min
- Storage: Room temperature
- Transportation: by courier
- LimitNum: 1 Gram
- Transportation: by courier
Superiority
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:
1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
Our advantage:
1. Higest quality and good package
2.Fast delivery
3.Better payment term
4.Fast response to customer within 6 hours
5.Good business credit in Europe ,US ,Japan ,Korea
Anyway ,if you need any chemicals from China ,Henan Tianfu can help you
Details
| Product Name: | Canertinib dihydrochloride |
| Synonyms: | CANERTINIB DIHYDROCHLORIDE;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride;Canertinib.2HCL;CI-1033;N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride;Canertinib HCl;CI 103 |
| CAS: | 289499-45-2 |
| MF: | C24H27Cl3FN5O3 |
| MW: | 558.86 |
| EINECS: | |
| Product Categories: | API;Inhibitors |
| Mol File: | 289499-45-2.mol |
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| Canertinib dihydrochloride Chemical Properties |
| storage temp. | 20°C |
| solubility | DMSO: >10mg/mL |
| Canertinib dihydrochloride Usage And Synthesis |
| Uses | CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively. |
| Uses | The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors. Canertinib is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively. As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM). Canertinib also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein. |