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NewblueCHEM--13171-25-0--Trimetazidine dihydrochloride CAS NO.13171-25-0
- FOB Price: USD: 800.00-800.00 /Metric Ton Get Latest Price
- Min.Order: 1 Metric Ton
- Payment Terms: L/C,T/T
- Available Specifications:
1(1-2)Metric Ton
- Product Details
Keywords
- TIANFUCHEM--13171-25-0--Trimetazidine dihydrochloride
- TIANFUCHEM--13171-25-0--Trimetazidine dihydrochloride
- TIANFUCHEM--13171-25-0--Trimetazidine dihydrochloride
Quick Details
- ProName: NewblueCHEM--13171-25-0--Trimetazidine...
- CasNo: 13171-25-0
- Molecular Formula: C14H24Cl2N2O3
- Appearance: white powder
- Application: Pharmaceutical intermediates
- DeliveryTime: in stock
- PackAge: bag
- Port: China main port
- ProductionCapacity: 1 Metric Ton/Day
- Purity: 99%
- Storage: Room temperature
- Transportation: BY SEA
- LimitNum: 1 Metric Ton
- Heavy metal: N/A
- Grade: Industrial Grade
- Transportation: N/A
Superiority
Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:
1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
Our advantage:
1. Higest quality and good package
2.Fast delivery
3.Better payment term
4.Fast response to customer within 6 hours
5.Good business credit in Europe ,US ,Japan ,Korea
Anyway ,if you need any chemicals from China ,Henan Newblue can help you
Details
Product Name:Trimetazidine dihydrochlorideSynonyms:1-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DIHYDROCHLORIDE;TRIMETAZIDINE DI HCL;TRIMETAZIDINE DIHYDROCHLORIDE;TRIMETAZIDINE HYDROCHLORIDE;TRIMETAZIDINE 2HCL;1-((2,3,4-trimethoxyphenyl)methyl)-piperazindihydrochloride;1-(2,3,4-trimethoxybenzyl)-piperazindihydrochloride;kyurinettCAS:13171-25-0MF:C14H24Cl2N2O3MW:339.26EINECS:236-117-0Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;C14 to C15;Chemical Synthesis;Heterocyclic Building Blocks;PiperazinesMol File:13171-25-0.mol
Trimetazidine dihydrochloride Chemical Properties
Melting point 231-235 °C(lit.)
storage temp. RefrigeratorMerck 14,9705CAS DataBase Reference13171-25-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,XiRisk Statements 22-36/37/38Safety Statements 26-36WGK Germany 3
RTECS TM2976100
HazardClass IRRITANT
MSDS Information
ProviderLanguageSigmaAldrichEnglish
Trimetazidine dihydrochloride Usage And Synthesis
DescriptionTrimetazidine dihydrochloride is the dihydrochloride salt of Trimetazidine. It is a drug used for the treatment of angina pectoris. It is capable of improving the left ventricular function in diabetic patients suffering coronary heart disease as well as treating the symptoms of patients suffering heart failure of different etiologies. It takes effects through acting as an anti- ischemic metabolic agent being capable of improving the utilization efficiency of myocardial glucose by inhibiting the metabolism of fatty acid (through inhibiting the activity of mitochondrial long- chain 3-ketoacyl coenzyme A Thiolase). The shift from fatty acid oxidation to glucose oxidation optimizes cellular energy process in cells exposed to hypoxia or ischaemia, further maintaining the intracellular ATP levels and ensuring the normal function of ionic pumps and transmembrane sodium-potassium flow to maintain cellular homeostasis.ReferencesFragasso, G, et al. "A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure. " Journal of the American College of Cardiology 48.5 (2006):992.
Tuunanen, H, et al. "Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy."Circulation 118.12(2008):1250.
Kantor, P. F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase."Circulation Research 86.5(2000):580.
Stanley, W. C., and M. Marzilli. "Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine. "Fundamental & Clinical Pharmacology 17.2(2003):133–145.
Kantor, Paul F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase." Circulation research 86.5 (2000): 580-588.Chemical PropertiesCrystalline SolidUsesAntianoxicUsesCoronary vasodilator. Antianginal
Trimetazidine dihydrochloride Chemical Properties
Melting point 231-235 °C(lit.)
storage temp. RefrigeratorMerck 14,9705CAS DataBase Reference13171-25-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,XiRisk Statements 22-36/37/38Safety Statements 26-36WGK Germany 3
RTECS TM2976100
HazardClass IRRITANT
MSDS Information
ProviderLanguageSigmaAldrichEnglish
Trimetazidine dihydrochloride Usage And Synthesis
DescriptionTrimetazidine dihydrochloride is the dihydrochloride salt of Trimetazidine. It is a drug used for the treatment of angina pectoris. It is capable of improving the left ventricular function in diabetic patients suffering coronary heart disease as well as treating the symptoms of patients suffering heart failure of different etiologies. It takes effects through acting as an anti- ischemic metabolic agent being capable of improving the utilization efficiency of myocardial glucose by inhibiting the metabolism of fatty acid (through inhibiting the activity of mitochondrial long- chain 3-ketoacyl coenzyme A Thiolase). The shift from fatty acid oxidation to glucose oxidation optimizes cellular energy process in cells exposed to hypoxia or ischaemia, further maintaining the intracellular ATP levels and ensuring the normal function of ionic pumps and transmembrane sodium-potassium flow to maintain cellular homeostasis.ReferencesFragasso, G, et al. "A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure. " Journal of the American College of Cardiology 48.5 (2006):992.
Tuunanen, H, et al. "Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy."Circulation 118.12(2008):1250.
Kantor, P. F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase."Circulation Research 86.5(2000):580.
Stanley, W. C., and M. Marzilli. "Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine. "Fundamental & Clinical Pharmacology 17.2(2003):133–145.
Kantor, Paul F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase." Circulation research 86.5 (2000): 580-588.Chemical PropertiesCrystalline SolidUsesAntianoxicUsesCoronary vasodilator. Antianginal