Seratrodast

English Synonyms: benzeneheptanoic acid, - (2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien- 1,4-benzoquinon-2-yl) -7-phenylheptanoicacid; aa-2414; beta- (2,4,5-trimethyl-3,6- dioxo-1,4-cyclohexadien- - (2,4,5-trimethyl-3,6 -dioxo-1,4-cyclohexadien-1-yl) benzeneheptanoic acid; 7- (3,5,6-trimethy1-1,4- ) -7-phenylheptanoic acid; 7-phenyl-7- (2,4,5-trimethyl-3,6-dioxo-1-cyclohexa-1,4-dienyl) heptanoic acid;

CAS number: 112665-43-7

Molecular formula: C22H26O4

Molecular weight: 354.44

EINECS number:

Related Categories: ZAGAM; Other Research APIs; Pharmaceutical Ingredients; Small Molecule Inhibitors; Pharmaceutical Ingredients (Research and Experimental Use); API; Heterocyclic Compounds; Intermediates & Fine Chemicals; Pharmaceuticals; medicine

Mol file: 112665-43-7.mol

Sequedit

Sequed Stuff Nature

Melting point 118-120 ° C

Store at + 4 ° C

Merck 14,8459

CAS Database 112665-43-7 (CAS DataBase Reference)

Sequed Uses and Methods of Synthesis

Overview Tracheal asthma is a chronic airway allergic disease involving many inflammatory cells such as eosinophils, mast cells and T lymphocytes. In recent years, significant progress has been made in the study of the pathogenesis of asthma. It has been recognized that inflammatory mediators such as thromboxane, prostaglandin, and platelet activating factor cause airway mucosal edema, infiltration of inflammatory cells, increased secretion of glands and blockage of intraluminal mucus plug An important mechanism of asthma. Therefore, the development and application of anti-asthmatic drugs directed against the inflammatory mediators mentioned above have also been taken seriously. At present, the main clinical treatment of asthma by steroidal anti-inflammatory drugs and bronchodilators and so on. Steroid anti-inflammatory drugs for the treatment of asthma effect is affirmative, but its role is too wide, the lack of specificity, long-term use of hypothalamic pituitary secretion of adrenocorticotropic hormone can be suppressed, and make the skin thin, bone loss , Children even lead to growth inhibition and so on. In addition, some asthma patients already have resistance to steroidal anti-inflammatory drugs. Bronchodilators also have significant side effects when given in high doses. Therefore, clinically urgent new anti-asthma drugs, this drug should have a reliable, safe, convenient administration, the characteristics of patient compliance characteristics, including thromboxane A (TXA2) receptor antagonist - The treatment has received widespread attention.