HENAN NEW BLUE CHEMICAL CO.,LTD

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HENAN NEW BLUE CHEMICAL CO.,LTD

Country: China (Mainland)Business Type: Lab/Research institutions

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  • Mr.Nolan
  • Ms. Jane Kong

Contact US
Ms.Daisy He
Tel: 371-55170693
  • Fax: 86-371-55170690
  • URL: http://www.newbluechem.com
  • Province/state: Henan
  • City: Zhengzhou
  • Street:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China
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Newblue CHEM PLERIXAFOR

Newblue CHEM PLERIXAFOR CAS NO.110078-46-1

  • Min.Order: 1 Gram
  • Payment Terms: L/C,D/A,D/P,T/T,
  • Product Details

Keywords

  • PLERIXAFOR
  • 110078-46-1
  • TIANFU CHEM PLERIXAFOR

Quick Details

  • ProName: Newblue CHEM PLERIXAFOR
  • CasNo: 110078-46-1
  • Molecular Formula: C28H54N8
  • Appearance: Solid
  • Application: Intermediates
  • DeliveryTime: according to client's demand quantity
  • PackAge: as requested
  • Port: SHANGHAI
  • ProductionCapacity: 1 Kilogram/Week
  • Purity: 98%
  • Storage: room temp
  • Transportation: by sea, by air or by courier
  • LimitNum: 1 Gram

Superiority

Our company was built in 2009 with an ISO certificate.

In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

 

Our main business covers the fields below:

 

1.Noble Metal Catalysts (Pt.Pd...)

2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)

3.OLED intermediates (Fluorene,Carbazole,Boric acid...)

4.Customs Synthesis

 

Our advantage:

1.Higest quality and good package

2.Fast delivery

3.Better payment term

4.Fast response to customer  within 6 hours

5.Good business credit in Europe ,US ,Japan ,Korea

Details

Product Name: PLERIXAFOR
Synonyms: PLERIXAFOR;1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane;1,4,8,11-Tetraazacyclotetradecane, 1,1'-(1,4-phenylenebis(methylene))bis-;Mozobil;Sdz sid 791;Unii-S915p5499n;1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane;Plerixafor(AMD3100)
CAS: 110078-46-1
MF: C28H54N8
MW: 502.791
EINECS:
Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 110078-46-1.mol
PLERIXAFOR Structure
PLERIXAFOR Chemical Properties
Melting point  122-125°C
density  0.962
storage temp.  Refrigerator

PLERIXAFOR Usage And Synthesis
Description Plerixafor (AMD3100) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively.
In vitro Plerixafor inhibits CXCL12-mediated chemotaxis with a potency lightly better than its affinity for CXCR4. Plerixafor also antagonizes SDF-1/CXCL12 ligand binding with an IC50 of 651 nM. Plerixafor inhibits SDF-1 mediated GTP-binding, SDF-1 mediated calcium flux and SDF-1 stimulated chemotaxis with IC50 of 27 nM, 572 nM and 51 nM, respectively. Plerixafor does not inhibit calcium flux against cells expressing CXCR3, CCR1, CCR2b, CCR4, CCR5 or CCR7 when stimulated with their cognate ligands, nor does Plerixafor inhibit receptor binding of LTB4. Plerixafor does not, on its own, induce a calcium flux in the CCRF–CEM cells, which express multiple GPCRs including CXCR4, CCR4 and CCR7.
In vivo A single topical application of Plerixafor promotes wound healing in diabetic mice by increasing cytokine production, mobilizing bone marrow EPCs, and enhancing the activity of fibroblasts and monocytes/macrophages, thereby increasing both angiogenesis and vasculogenesis. Cohorts of mice are administered with PBS, IGF1, PDGF, SCF, or VEGF for five consecutive days and Plerixafor on the 5th day. The number and size of the colonies are highest in IGF1 plus Plerixafor injected mice compared to PDGF, SCF and VEGF treated groups, in combination with Plerixafor.
Chemical Properties White Solid
Uses Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively
Uses Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in p atients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).

 

 

 

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